34. Zapol WM, Snider MT, Hill JD, et al. Extracorporeal membrane oxygenation in severe acute respiratory failure. A
randomized prospective study. JAMA 1979;242:2193–6.
35. Morris AH, Wallace CJ, Menlove RL, et al. Randomized
clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. Am J Respir Crit Care Med
1994;149:295–305.
36. Australia and New Zealand Extracorporeal Membrane
Oxygenation (ANZ ECMO) Influenza Investigators, Davies
A, Jones D, Bailey M, et al. Extracorporeal Membrane
Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA 2009;302:1888–95.
37. Patroniti N, Zangrillo A, Pappalardo F, et al. The Italian ECMO
network experience during the 2009 influenza A(H1N1)
pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med 2011;37:1447–57.
38. Noah MA, Peek GJ, Finney SJ, et al. Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1).
JAMA 2011;306:1659–68.
39. Pham T, Combes A, Roze H, et al. Extracorporeal membrane oxygenation for pandemic influenza A(H1N1)-in-
duced acute respiratory distress syndrome: a cohort study
and propensity-matched analysis. Am J Respir Crit Care
Med 2013;187:276–85.
40. Peek GJ, Mugford M, Tiruvoipati R, et al. Efficacy and
economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for
severe adult respiratory failure (CESAR): a multicentre
randomised controlled trial. Lancet 2009;374:1351–63.
41. Schmidt M, Bailey M, Sheldrake J, et al. Predicting survival
after extracorporeal membrane oxygenation for severe
acute respiratory failure. The Respiratory Extracorporeal
Membrane Oxygenation Survival Prediction (RESP) score.
Am J Respir Crit Care Med 2014;189:1374–82.
42. Downs JB, Stock MC. Airway pressure release ventilation: a new concept in ventilatory support. Crit Care Med
1987;15:459–61.
43. Daoud EG, Farag HL, Chatburn RL. Airway pressure
release ventilation: what do we know? Respir Care
2012;57:282–92.
44. Esteban A, Alia I, Gordo F, et al. Prospective randomized
trial comparing pressure-controlled ventilation and volume-controlled ventilation in ARDS. For the Spanish Lung Failure Collaborative Group. Chest 2000;117:1690– 6.
45. Huang CC, Shih MJ, Tsai YH, et al. Effects of inverse ratio
ventilation versus positive end-expiratory pressure on gas
exchange and gastric intramucosal PCO( 2) and pH under
constant mean airway pressure in acute respiratory distress syndrome. Anesthesiology 2001;95:1182–8.
46. Rappaport SH, Shpiner R, Yoshihara G, et al. Randomized, prospective trial of pressure-limited versus volume-controlled ventilation in severe respiratory failure. Crit Care
Med 1994;22:22–32.
47. Hering R, Peters D, Zinserling J, et al. Effects of spontaneous breathing during airway pressure release ventilation
on renal perfusion and function in patients with acute lung
injury. Intensive Care Med 2002;28:1426–33.
48. Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling
J. Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with
acute respiratory distress syndrome. American journal of
respiratory and critical care medicine 1999;159:1241-8.
49. Putensen C, Zech S, Wrigge H, et al. Long-term effects
of spontaneous breathing during ventilatory support in
patients with acute lung injury. Am J Respir Crit Care Med
2001;164:43–9.
50. Andrews PL, Shiber JR, Jaruga-Killeen E, et al. Early application of airway pressure release ventilation may reduce
mortality in high-risk trauma patients: a systematic review
of observational trauma ARDS literature. J Trauma Acute
Care Surg 2013;75:635–41.
51. Maxwell RA, Green JM, Waldrop J, et al. A randomized
prospective trial of airway pressure release ventilation
and low tidal volume ventilation in adult trauma patients
with acute respiratory failure. J Trauma 2010;69:501–10;
discussion 11.
52. Ketoconazole for early treatment of acute lung injury and
acute respiratory distress syndrome: a randomized controlled trial. The ARDS Network. JAMA 2000;283:1995–
2002.
53. Abraham E, Baughman R, Fletcher E, et al. Liposomal
prostaglandin E1 (TLC C-53) in acute respiratory distress
syndrome: a controlled, randomized, double-blind, multicenter clinical trial. TLC C-53 ARDS Study Group. Crit
Care Med 1999;27:1478–85.
54. Vincent JL, Brase R, Santman F, et al. A multi-centre,
double-blind, placebo-controlled study of liposomal prostaglandin E1 (TLC C-53) in patients with acute respiratory
distress syndrome. Intensive Care Med 2001;27:1578–83.
55. Randomized, placebo-controlled trial of lisofylline for early
treatment of acute lung injury and acute respiratory distress syndrome. Crit Care Med 2002;30: 1–6.
56. Anzueto A, Baughman RP, Guntupalli KK, et al. Aerosolized surfactant in adults with sepsis-induced acute
respiratory distress syndrome. Exosurf Acute Respiratory
Distress Syndrome Sepsis Study Group. N Engl J Med
1996;334:1417–21.
57. Spragg RG, Lewis JF, Walmrath HD, et al. Effect of
recombinant surfactant protein C-based surfactant on
the acute respiratory distress syndrome. N Engl J Med
